MIV Therapeutics Further Expands IP Portfolio with Milestone Addition of Two New U.S. Provisional Patent Applications Tuesday August 30, 8:24 pm ET
Leading Biomedical Innovator Provides New Coating Technologies for Next Generation of Drug-Eluting Implantable Medical Devices
VANCOUVER, British Columbia--(BUSINESS WIRE)--Aug. 30, 2005--MIV
Therapeutics, Inc. (OTCBB:MIVT - News), a developer of next-generation
biocompatible passive and drug-eluting stent coatings and drug
delivery technologies for the treatment of cardiovascular disease,
announced today a major milestone in further expanding its
intellectual property rights with the filing of two new U.S. patent
applications by the University of British Columbia, a technology
development partner of MIVT.
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The two patent applications pertain to technologies for
effectively applying novel coatings onto metal medical devices to
achieve desired therapeutic benefits. Both of these technologies carry
considerable potential to improve the therapeutic functionality of
implantable medical devices, such as metal stents.
"These latest technological leaps provide additional validation of
our innovation and potential to significantly impact the biomedical
marketplace," said CEO Alan Lindsay. "By continuing to expand this
valuable intellectual property portfolio, we are not only effectively
safeguarding our Company's commercial viability and competitive edge,
but also potentially contributing to the advancement and enhancement
of critical medical care. These latest patent applications are a
source of great pride and gratification to our team and to the ceramic
scientists at the University of British Columbia."
Significantly, these technologies build on earlier coating
technologies developed by MIVT, which could have a substantial impact
on the methods in which metal medical devices will be coated in the
future to achieve optimal biocompatibility, safety and efficacy.
Unlike the medical coatings commonly in use today, MIVT's
proprietary "HAp" coatings are based on a substance that is already
naturally found in the human body known as hydroxyapatite. MIVT's
innovative coating technologies are designed to inhibit adverse
reactions of the immune system.
MIV Therapeutics is committed to providing improved solutions for
the treatment of cardiovascular disease and other conditions. In
collaboration with the University of British Columbia, MIVT is focused
on developing proprietary HAp coating formulations to protect
surrounding tissue from chemical interaction with bare-metal stents,
an interaction which typically causes an aggressive immune response,
resulting in restenosis, or re-narrowing of arteries, and a risk of
thrombus in the stented artery.
MIVT's novel coatings are based upon a natural material,
Hydroxyapatite, a component of hard tissue found in human teeth and
bone, which enables the surface of metallic stents to virtually mimic
the natural state of structurally-sound 100% biocompatible and
bio-active tissue.
The Company believes its technology also has potential for an
array of additional medical applications, including dental, hip and
bone repair implants.
About MIV Therapeutics, Inc.
MIV Therapeutics, Inc. is developing a next-generation line of
advanced biocompatible coatings for passive and drug-eluting
application on cardiovascular stents and for application on other
implantable medical devices. The Company's ultra-thin coating
formulation is designed primarily to protect surrounding tissue from
the chemical interaction with metal stents. The Company's unique
ultra-thin coating has been derived from a biocompatible material
called hydroxyapatite (HAp) that during in-vivo animal trials
demonstrated excellent safety and superior healing properties pursued
by the science in the field of advanced implantable drug delivery
systems. Hydroxyapatite is a bioactive porous material that makes up
the bone mineral and matrix of teeth. It is widely used as a bone
substitute material and for coating implantable fixation devices in
orthopedic, dental and other applications. The Company's novel drug
eluting technologies based on Hydroxyapatite provide attractive
alternative solution to polymer-based drug eluting coatings currently
in the stent market. The Company's drug eluting coating is designed to
suit a broad range of implantable medical devices which may benefit
from a highly customizable drug release profile. MIVT reached a
Collaborative Research Agreement (CRA) with the University of British
Columbia and supported a research and development grant from the
Natural Sciences and Engineering Research Council of Canada (NSERC) in
2002 for the development of Hydroxyapatite as a drug-eluting coating.
In December 2004 MIVT received a Government grant for the research
program titled "Development of Novel Drug Eluting Composite Coatings
for Cardiovascular Stents" under the National Research Council --
Industrial Research Assistance Program (NRC-IRAP). Under this
sponsorship the Company will progress to the development stage, which
is expected to finalize the drug-eluting research and development
Program. For more information, please visit:
http://www.trilogy-capital.com/tcp/mivt/website.html. To read or
download MIV Therapeutics' Investor Fact Sheet, visit
http://www.trilogy-capital.com/tcp/mivt/factsheet.html. To obtain
daily and historical Company stock quote data, and recent Company news
releases, visit http://www.trilogy-capital.com/tcp/html/mivt.htm.
Forward-Looking Statements
Except for the historical information contained herein, the
matters discussed in this press release are forward-looking
statements. Such statements are indicated by words or phrases such as
"believe," "will," "breakthrough," "significant," "indicated," "feel,"
"revolutionary," "should," "ideal," "extremely" and "excited." These
statements are made under "Safe Harbor" provisions of the Private
Securities Litigation Reform Act of 1995. Actual results may differ
materially from those described in forward-looking statements and are
subject to risks and uncertainties. See the Company's filings with the
Securities and Exchange Commission including, without limitation, the
Company's recent Form 10-K and Form 10-Qs, which identify specific
factors that may cause actual results or events to differ materially
from those described in the forward-looking statements.
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